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目的探讨白血病抑制因子(leukemia inhibitory factor,LIF)的表达与稽留流产的关系。方法选择30例稽留流产患者为观察组,同期自愿选择人工流产术终止妊娠的正常早孕妇女30例为对照组,用免疫组化链酶素抗生物蛋白—过氧化物酶连接(streptavidin-perosidase,SP)法检测LIF在两组绒毛及蜕膜组织中的表达情况。结果①LIF在绒毛组织中表达于滋养细胞胞浆中;在蜕膜组织中表达于腺体细胞胞浆。②LIF在两组蜕膜组织中的表达均明显高于绒毛组织,差异有统计学意义(P<0.05)。③LIF在观察组绒毛及蜕膜组织中的表达较对照组明显降低,差异有统计学意义(P<0.05)。结论 LIF在绒毛及蜕膜组织中的表达强度降低,胚胎着床后发育不良导致稽留流产。
Objective To investigate the relationship between leukemia inhibitory factor (LIF) expression and missed abortion. Methods Thirty patients with missed abortion were selected as the observation group. Thirty normal pregnant women who chose to abort the induced abortion during the same period were selected as the control group. The streptavidin-perosidase SP) was used to detect the expression of LIF in both villus and decidua. Results ①LIF was expressed in trophoblastic cytoplasm in villus tissues and cytoplasm in glandular cells in decidua tissues. ② The expression of LIF in decidua was significantly higher than that in villus, the difference was statistically significant (P <0.05). ③ The expression of LIF in the observation group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusions The expression of LIF in the villi and decidua is decreased, and the dysplasia after implantation of the embryo leads to missed abortion.