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目的系统评价右佐匹克隆对比佐匹克隆治疗失眠症的疗效与安全性。方法检索数据库(Pubmed、CNKI等),查阅自2005—2014年发表的有关右佐匹克隆对比佐匹克隆治疗失眠症的相关文献。纳入随机对照试验,进行方法质量评价,使用RevMan5.3软件进行数据分析。结果纳入12篇随机对照试验文献,共计1490例患者。Meta分析结果显示,右佐匹克隆组总有效率高于佐匹克隆组,结果有统计学意义。右佐匹克隆组睡眠障碍评定量表减分率和不良反应发生率低于佐匹克隆组,但结果无统计学差异。两组药物的显效率相当。结论右佐匹克隆治疗失眠症的疗效优于佐匹克隆,安全性相当。
Objective To evaluate the efficacy and safety of dexrazoxane in comparison with zopiclone in the treatment of insomnia. (Pubmed, CNKI, etc.), consult the literature published since 2005-2014 on the treatment of insomnia by tezocidol versus zopiclone. Randomized controlled trials were included to evaluate the quality of the method and RevMan5.3 software was used for data analysis. Results A total of 1490 patients were enrolled in 12 randomized controlled trials. Meta-analysis showed that the total effective rate of the right zopiclone group was higher than that of zopiclone, the results were statistically significant. The detriment rate and adverse reactions of dexrazoxane in sleep disorder assessment scale were lower than that of zopiclone, but the results were not statistically different. The two groups of drugs markedly efficient. Conclusion The efficacy of dexrazepam in the treatment of insomnia is superior to that of zopiclone, and its safety is comparable.