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英《新科学家》第90卷第1256期(1981年)报道:自从发现鸦片样肽类物质以来,就努力想把这些自然止痛药的结构应用于设计新的、更有效的止痛药。由木苏领导的一个日本研究小组,最近已制备出在结构上相似的小分子鸦片样肽类物(脑啡肽),这种物质有较吗啡更强的止痛作用,有关的内容已在德国的《自然》杂志第68卷第20页刊载。所有的鸦片样肽类物质是从β-脂肪酸释放激素的前体分子衍生的。β-脂肪酸释放激素是由肽键连接的91个氨基酸分子组成。这样前体
The British New Scientist, Vol. 90, No. 1256 (1981) reported that since the discovery of opioid peptides, efforts have been made to apply the structure of these natural painkillers to the design of new, more effective pain killers. A Japanese research group led by Mu Su has recently prepared a structurally similar small molecule opioid peptide (enkephalin), which has a stronger analgesic effect than morphine, and the relevant content is already in Germany. The 68th volume of Nature magazine is published on page 20. All of the opiate-like peptides are derived from the precursor molecules of the β-fatty acid releasing hormones. The beta fatty acid releasing hormone is composed of 91 amino acid molecules linked by peptide bonds. Precursor