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在人体内从葡萄糖合成的右旋氨基葡萄糖(DG)是自体生物素单糖,用于合成葡糖胺聚糖和糖蛋白。化学合成纯品硫酸氨基葡萄糖(GS)用于治疗骨关节炎病,po、im或tv给药后很快被吸收且分解为DG和硫酸离子。研究其药动学有两个难点:()体内可合成DG且不能作为母体化合物回收;
Dextran (DG) synthesized from glucose in the human body is an autologous biotin monosaccharide used to synthesize glycosaminoglycans and glycoproteins. Chemically synthesized pure glucosamine sulfate (GS) is used to treat osteoarthritis and is quickly absorbed and decomposed into DG and sulfate ions after po, im or tv administration. There are two difficulties in studying its pharmacokinetics: (1) DG can be synthesized in vivo and can not be recovered as a parent compound;