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目的 :探讨放射性胸膜炎的发病机制及氟伐他汀的防治作用。方法 :将 98只雌性SD大鼠分为正常对照组 ( 10只 ) ,单纯照射组 ( 38只 )和氟伐他汀防治组 ( 5 0只 )。防治组于照射前 1周每只每天按 2 0mg/kg氟伐他汀灌胃 ,直至活杀 ,其他组灌服等量生理盐水。单纯照射组与氟伐他汀防治组行直线加速器全胸部照射 ,剂量为单次2 0Gy。照射后 5 ,15 ,30 ,6 0d按 4 0mg/kg硫喷妥钠腹腔内注射 ,麻醉后剪开胸腔 ,有胸水者抽取胸水进行常规及生化检查 ,细菌培养 ,并取肺组织以甲醛溶液固定 ,作病理切片检查。数据采用 χ2 检验。结果 :88只大鼠在照射后31～ 6 0d ,2 7只发生放射性胸膜炎 ,总发生率为 30 .7%。其中单纯照射组发生率为 4 2 .1% ( 16 /38) ,氟伐他汀防治组发生率为 2 2 % ( 11/5 0 ) ,χ2 值为 4 .10。与单纯照射组相比 ,氟伐他汀防治组放射性胸膜炎明显减少 ,而且病理改变也较轻 (P <0 .0 5 )。结论 :放射性胸膜炎在放射性肺损伤的早期即可出现 ,氟伐他汀能有效防治放射性胸膜炎的发生与发展
Objective: To investigate the pathogenesis of radiation pleuritis and the preventive and therapeutic effects of fluvastatin. Methods: 98 female SD rats were divided into normal control group (n = 10), irradiation group (n = 38) and fluvastatin control group (n = 50). The control group was treated with fluvastatin 20 mg / kg every day for one week before irradiation until the mice were killed. The other groups were given the same amount of saline. The pure irradiation group and the fluvastatin control group were treated with a linear accelerator with a total chest irradiation dose of 20 Gy. After irradiation 5, 15, 30, 60d by 40mg / kg thiopental sodium intraperitoneal injection, after thoracotomy anesthesia, pleural effusion with pleural effusion routine and biochemical examination, bacterial culture, and take lung tissue with formaldehyde solution Fixed, for biopsy. Data using χ2 test. Results: In the 88 rats, 31 to 60 days after irradiation, radioactive pleuritis occurred in 27 cases, with a total incidence of 30.7%. Among them, the incidence of simple irradiation group was 42.1% (16/38), the incidence of fluvastatin control group was 22% (11/5 0), and the χ2 value was 4.10. Compared with the simple irradiation group, the fluvastatin control group had a significant reduction in the number of radiation pleuritis, and the pathological changes were also lighter (P <0.05). Conclusions: Radiation pleurisy can occur in the early stage of radiation-induced lung injury. Fluvastatin can effectively prevent and treat the occurrence and development of radiation pleuritis