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目的 :观察 rh EPO对多发性骨髓瘤 (MM)合并贫血的治疗作用。方法 :随机选择 2 0例诊断明确的初治的多发性骨髓瘤患者 ,按照诊断标准判断均为 期的患者 ,随机分为两组 ,一组为rh EPO治疗组 ,一组为对照组 ,治疗组病例均于治疗前进行血清 rh EPO水平、铁蛋白、血清铁、血常规、红细胞压积和网织红细胞计数的检测。应用国产的 rh EPO,剂量为 15 0 U/ kg,每周 3次 ,皮下注射 ,治疗 4周～ 6周。治疗期间每天进行血压的检测 ;每 3天进行 1次血常规、网织红细胞计数及红细胞压积的检测 ;每 2周进行 1次血清 EPO水平的检测及血清铁、铁蛋白的检测。结果 :rh EPO治疗组80 %的患者均于治疗后 1周～ 2周出现血红蛋白上升 10 g/ L～ 2 0 g/ L,2 0 %的患者血红蛋白上升不够显著 ,为 5 g/ L～ 10 g/ L,但是 ,输血的间隔时间均较对照组延长 ,而且 ,生存质量亦较对照组明显提高。特别是内源性 EPO水平较低者疗效更佳。结论 :rh EPO对 MM合并贫血有较好的治疗作用。同时可以减少输血治疗和延长输血间隔时间
Objective: To observe the therapeutic effect of rh EPO on multiple myeloma (MM) complicated with anemia. Methods: Twenty patients with newly diagnosed multiple myeloma were randomly selected and randomly divided into two groups according to the diagnostic criteria. One group was rh EPO treatment group, the other was control group. The treatment group All cases were examined before treatment, serum rh EPO levels, ferritin, serum iron, blood tests, hematocrit and reticulocyte counts. Application of domestic rh EPO, a dose of 15 0 U / kg, 3 times a week, subcutaneous injection, the treatment of 4 weeks to 6 weeks. The blood pressure was measured every day during treatment. Blood routine test, reticulocyte count and hematocrit test were performed every 3 days. Serum levels of EPO and serum iron and ferritin were measured every 2 weeks. Results: In the rh EPO group, the hemoglobin level increased from 10 g / L to 20 g / L in 1 week to 2 weeks after treatment, and the hemoglobin level in 20% of patients did not increase significantly from 5 g / L to 10 g / L, however, the interval of blood transfusion was longer than the control group, and the quality of life was also significantly improved compared with the control group. In particular, the lower the level of endogenous EPO better effect. Conclusion: rh EPO has a good therapeutic effect on MM with anemia. At the same time can reduce blood transfusion and prolong the interval of blood transfusion