由于抗菌素及皮质类固醇的广泛应用,霉菌性角膜炎的发病率明显增加,但常用的抗霉菌药物毒性大、疗效差,使霉菌性角膜炎成为临床治疗的一个难问题。氟康唑(Fluconazole)是新近推出的一种广谱全身、局部均可用的抗霉菌药物,具有水溶性、与血浆蛋白结合低、半衰期长等优点。我们在国内首次在眼科应用法国产氟康唑治疗两例用其它抗霉菌药物治疗无效的霉菌性角膜炎,取得了良好的临床效果。现报告如下:例1 女21岁患者因右眼红,伴轻度畏光、眼痛两天来本科就诊。既往右眼有单疱病毒性角膜炎史4年,反复发作多次。检查:右视力0.2~(+(?))、J_(?),右眼无明显刺激症状,睫状充血(+),角膜颞上部 Due to the widespread use of antibiotics and corticosteroids, the incidence of mycotic keratitis increased significantly, but the commonly used anti-fungal drug toxicity, poor efficacy, fungal keratitis become a difficult clinical treatment. Fluconazole is a newly introduced broad-spectrum systemic and locally available anti-fungal drug with the advantages of water solubility, low binding to plasma proteins and long half-life. We have the first clinical application of fluconazole in the ophthalmic application of two cases of mycotic keratitis with other antimycotic drugs ineffective treatment, and achieved good clinical results. Now report as follows: Example 1 Female 21 years old because of right eye red, with mild photophobia, eye pain two days to undergraduate treatment. Past history of herpes simplex keratitis has a history of 4 years, repeated episodes many times. Check: right visual acuity 0.2 ~ (+ (?)), J_ (?), Right eye no obvious irritation, ciliary congestion (+), corneal temporal superior