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目的 以氟伐他汀为参照研究沥水调脂胶囊的调脂和抗动脉粥样硬化的疗效和安全性。方法 将 6 0例高脂血症病人随机单盲分为两组 ,分别投以沥水调脂胶囊和氟伐他汀 ,疗程 8周 ,观察调脂疗效、不良反应及对血浆一氧化氮 (NO)、氧化型低密度脂蛋白胆固醇 (oxLDL)水平的影响。结果 两组经治疗后TC、TG、LDL C、oxLDL、TC HDL C/HDL C显著性降低 ,HDL C均无显著性升高 ,血浆NO水平均有显著性升高 ,两组药物的不良反应均较轻微。以上各指标在治疗前后两组间比较差异均无显著意义。结论 沥水调脂胶囊的降脂疗效较确切 ,且不良反应少 ,值得临床推广应用。
Objective To study the efficacy and safety of fluvastatin as a reference for lipid-lowering and anti-atherosclerosis of Li Shui Tiao Zhi Capsule. Methods Sixty patients with hyperlipidemia were randomized into two groups randomly. Lishui tiaozhi capsule and fluvastatin were respectively administered for 8 weeks. The effects of lipid-lowering therapy, adverse reactions and the effects on plasma nitric oxide (NO) , Oxidized low density lipoprotein cholesterol (oxLDL) levels. Results After treatment, TC, TG, LDL C, oxLDL, TC HDL C / HDL C were significantly decreased, HDL C no significant increase, plasma NO levels were significantly increased, two groups of adverse drug reactions Are minor. The above indicators before and after treatment were no significant difference between the two groups. Conclusion Lishui Tiaozhi capsule lipid-lowering effect of more accurate, and less adverse reactions, it is worth promoting the clinical application.