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目的调查研究嘉兴地区无偿献血人群梅毒感染状况,为无偿献血者招募和血液初筛工作采取应对措施提供依据。方法对2009年-2013年共210 186份无偿献血者样本采用2个不同厂家的试剂进行检测,对单家或双家不合格样本用TPPA做确认试验。结果 2009年-2013年,每年单家或双家梅毒试剂检测总阳性率分别为0.39%、0.52%、0.54%、0.66%、0.71%,平均不合格率为0.57%,各年度梅毒检测阳性率比较差异有统计学意义(χ2=45.43,P<0.01);TPPA确认阳性率分别为0.31%、0.36%、0.42%、0.45%、0.48%,平均阳性率为0.41%,各年度梅毒阳性率比较差异有统计学意义(χ2=19.72,P<0.01);单家与双家试剂检测阳性经确认后阳性率比较,差异有统计学意义(P<0.05)。结论嘉兴地区无偿献血人群梅毒感染患者呈逐年增长态势,应加大对无偿献血者体检征询力度,加强街头检验初筛样本的梅毒快速检测,减少血液报废,保证临床血液安全。
Objective To investigate the status of syphilis infection in unpaid blood donors in Jiaxing area and provide evidence for the recruitment of blood donors and blood screening. Methods A total of 210 186 blood donors from 2009 to 2013 were tested with two reagents from different manufacturers. Confirmation tests were performed on single or double failed samples with TPPA. Results From 2009 to 2013, the total positive rates of single or double syphilis were 0.39%, 0.52%, 0.54%, 0.66% and 0.71%, respectively. The average unqualified rate was 0.57%. The positive rate of syphilis in each year The positive rates of TPPA were 0.31%, 0.36%, 0.42%, 0.45% and 0.48% respectively, with the average positive rate of 0.41%. The positive rate of syphilis in each year was significantly higher than that of the other two groups (χ2 = 45.43, P <0.01) The difference was statistically significant (χ2 = 19.72, P <0.01). The positive rate of single-agent and double-agent detection was significantly higher than that of control group (P <0.05). CONCLUSIONS: Syphilis infection in unpaid blood donors in Jiaxing area has been increasing year by year. Therefore, it is necessary to increase the consultation on unpaid blood donors and strengthen the rapid detection of syphilis in the primary screening samples of streets to reduce blood waste and ensure clinical blood safety.