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雷米普利(Ram)1mg/kg iv能使正常血压大鼠、豚鼠的收缩压(SAP),舒张压(DAP),平均动脉压(MAP)迅速而持久下降,伴有左室压(LVP),左室内压力最大变化速率(±dp/dt_(max))下降,30 min后LVP,±dp/dt_(max)恢复,而血压在90 min后仍明显低于给药前水平。血管紧张素I(ANG I)10μg/kg iv后,上述参数迅速上升,但为时短暂。先iv Ram 1mg/kg,20 min后注入ANG I,以上作用不再出现。 离体实验中,Ram 0.1和1 μmol/L使甲氧明收缩兔胸主动脉和肺动脉环的量效反应曲线平行右移,最大反应压低不明显,求得Ram在主动脉环和肺动脉环上拮抗甲氧明的pA_2值分别为6.48和7.02。
Ramipril 1mg / kg iv can rapidly and consistently reduce systolic blood pressure (SAP), diastolic blood pressure (DAP) and mean arterial pressure (MAP) in normal blood pressure rats and guinea pigs with left ventricular pressure (LVP ), The maximal rate of change of left ventricular pressure (± dp / dt max) decreased and LVP and ± dp / dt max recovered after 30 min, while the blood pressure was still significantly lower than pre-dose after 90 min. Angiotensin I (ANGI) 10μg / kg iv, the above parameters increased rapidly, but for a short time. The first iv Ram 1mg / kg, ANG I injected after 20 min, the above effect no longer appears. In vitro experiments, Ram 0.1 and 1 μmol / L of methoxylamine contraction of the rabbit thoracic aorta and pulmonary artery ring parallel to the right dose-response curve, the maximum reaction pressure is low, Obtain Ram in the aortic ring and pulmonary artery rings The pA 2 values of antagonistic methoxine were 6.48 and 7.02, respectively.