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目的探讨母婴血型不合新生儿溶血病(HDN)相关检测结果的相关性。方法对绵阳市中心医院2008年1月至2013年12月期间新生儿科180例发生新生儿溶血的患儿进行血型及三项实验检测(直接抗人球实验、血清游离抗体测试ABO血型系统以外的抗体筛查),并对产妇进行血型及Ig G抗体效价测定。结果三项实验可证实新生儿溶血病81例,可凝5例,不明确94例。产妇Ig G效价≥512时HDN发病率为91.66%,Ig G效价为256~时HDN发病率为72.92%,Ig G效价为128~时HDN发病率为57.69%,Ig G效价为64~时HDN发病率为28.57%,Ig G效价<64时HDN发病率为1.64%,各组间新生儿溶血病发病率差异有统计学意义(P<0.05)。结论产妇Ig G抗体效价与新生儿溶血病发病率呈正相关,因此在夫妇血型不合时孕妇应定期监测Ig G抗体效价,可降低HDN发病率。
Objective To investigate the correlation between maternal and neonatal blood group incompatibility with neonatal hemolytic disease (HDN). Methods One hundred and eighty children with neonatal hemolysis in the Department of Neonatology between January 2008 and December 2013 in Mianyang Central Hospital were tested for blood group and three experiments (direct anti-human sphere test, serum free antibody test except ABO blood group system Antibody screening), and maternal blood group and Ig G antibody titers. Results Three experiments confirmed that hemolytic disease in 81 cases, coagulation in 5 cases, 94 cases not clear. The incidence of HDN was 91.66% when IgG titers≥512, the HDN incidence was 72.92% when Ig G titers were 256 ~, and the incidence of HDN was 57.69% when Ig G titers were 128 ~ The incidence of HDN was 64.5% at 28.57%. The prevalence of HDN was 1.64% at IgA titer <64, and the incidence of hemolytic disease among neonates was statistically significant (P <0.05). Conclusion The titer of maternal Ig G antibody is positively correlated with the incidence of hemolytic disease in newborns. Therefore, pregnant women should periodically monitor IgG antibody titers and reduce the incidence of HDN.