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目的 :研究 Cyclin E、p2 1 /WAF1 /CIP1蛋白在结直肠癌组织中的表达水平及其与生物学行为和预后的关系。方法 :用免疫组化方法检测 5 5例结直肠癌组织中 P2 1 /WAF1 /CIP1、Cyclin E蛋白的表达。结果 :1 0例癌旁结直肠组织中 ,Cyclin E表达均为阴性 ,5 5例结直肠组织中 ,3 4例 Cyclin E表达阳性 ;1 0例癌旁结直肠组织中 ,p2 1表达均为阳性 ,5 5例结直肠癌组织中 2 5例 p2 1表达阳性 ;Cyclin E蛋白表达多见于浸润深、分化差、淋巴结转移、临床分期晚的结直肠癌组织中 ;p2 1 /WAF1 /CIP1蛋白表达多见于分化好、浸润浅、未发生淋巴结转移、临床分期较早的结直肠癌组织中 ;Cyclin E蛋白表达组的 5年生存率低于阴性组 ;p2 1 /WAF1 /CIP1蛋白表达组的 5年生存率高于阴性组。结论 :Cyclin E、p2 1 /WAF1 /CIP1可作为反映结直肠癌恶性生物学行为及预后的指标。
OBJECTIVE: To study the expression of Cyclin E, p21 / WAF1 / CIP1 protein in colorectal cancer and its relationship with biological behavior and prognosis. Methods: The expressions of P2 1 / WAF1 / CIP1 and Cyclin E in 55 colorectal cancer tissues were detected by immunohistochemistry. Results: The expression of Cyclin E was negative in 10 paracancer tissues and 34 of 55 colorectal tissues. The expression of p21 in 10 paracancer tissues was 25 cases of colorectal cancer tissue positive expression of p21; Cyclin E protein expression more common in deep infiltration, poorly differentiated, lymph node metastasis, clinical stage of colorectal cancer tissue late; p2 1 / WAF1 / CIP1 protein The expression of Cyclin E protein was significantly higher in well-differentiated, less invasive and no lymph node metastasis than in those with early clinical stage. The 5-year survival rate of Cyclin E protein expression group was lower than that in negative group. The expression of p21 / WAF1 / CIP1 protein 5-year survival rate was higher than negative group. Conclusion: Cyclin E, p2 1 / WAF1 / CIP1 can be used as indicators of malignant biological behavior and prognosis of colorectal cancer.