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1983年Rossle注意到肝病患者口服50mg/kg色氨酸后血浓度的半衰期延长,提出色氨酸耐量试验有助判断慢性肝病的程度。但口服法影响因素较多,本文用静脉法色氨酸耐量试验(Intravenous TryptophanTolerance Test,ITTT经动物急性毒理试验安全无毒后,遂对经手术及病理证实的64例病人进行研究。
In 1983, Rossle noticed a prolonged half-life of blood concentration in patients with liver disease after oral administration of 50 mg / kg tryptophan, and suggested that tryptophan tolerance test can help determine the degree of chronic liver disease. However, there are many influencing factors in oral administration. In this study, 64 cases of patients with pathologically confirmed liver disease were studied by Intravenous TryptophanTolerance Test (ITTT).