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为了观察棉尘病的发生及其自然发展史，对６０名棉纺厂新工人进行了５年的前瞻性随访。结果发现，接尘后出现咳嗽、咳痰及呼吸道刺激症状者在暴露初期较多，胸部紧束感在暴露１年时达高峰，且一直保持在较高的水平，分层分析未见其与吸烟及特异体质等因素有关。班后一秒钟用力呼气容积的下降随暴露时间延长呈现出逐渐加重的趋势，棉花抗原皮试阳性者表现尤为突出，而吸烟对此没有影响。说明暴露与特异体质两因素对肺功能的损伤起主要作用
In order to observe the occurrence of cotton dust disease and its natural history, 60 cotton mill new workers were prospectively followed up for 5 years. The results showed that after the dust exposure to cough, sputum and respiratory irritation were more in the early exposure, chest tightness flu peak at 1 year of exposure, and has remained at a high level, stratified analysis has not seen Smoking and specific physical and other factors. The decline in forced expiratory volume one second after the shift showed a gradual increase with the prolongation of exposure. The positive results of cotton antigen skin test were particularly prominent, while smoking had no effect on this. Explain the two factors of exposure and specific physical damage to lung function play a major role