【摘 要】
：
Intestinal stem cell (ISC) differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying (TA) cells.However,whether and how lymphocyte-stem/TA cell contact affects ISC differentiation is l
【机 构】
：
School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Scienc
论文部分内容阅读
Intestinal stem cell (ISC) differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying (TA) cells.However,whether and how lymphocyte-stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell-stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrin αEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.Blocking αEβ7-E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7+ T cells regulate ISC differentiation at single-cell level through cell-cell contact-mediated αEβ7-E-cadherin adhesion signaling,highlighting a critical role of the T cell-stem/TA cell contact in maintaining intestinal homeostasis.
其他文献
The emergence of severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2) variants and new coronaviruses raise the demand for universal vaccines.In recent Science and Cell papers,Martinez et al.and Nathan et al.reported two novel approaches for vacci
The refractory response of pancreatic ductal adenocarcinoma(PDAC) to multiple treatment regimens can be attributed to the presence of a desmoplastic stroma together with an immunosuppressive tumor microenvironment.In a recent study published in Cell,Koika
以乌鲁木齐市为例,分析了多民族聚居城市基础教育设施空间布局特征,并采用社会区分析和多因子相关性检验,研究教育设施布局的社会空间差异.结果表明,乌鲁木齐市教育设施布局呈现核心-边缘结构特征,多数学校集中在天山区和沙依巴克区.扇面分析发现,教育设施以北偏西方向布局为主,教育设施布局沿城市发展主方向拓展.教育设施可达性和数量总体上与城市人口密度相协调,但存在一定空间错配.汉族和维吾尔族聚居街区可达性较高,哈萨克族和回族聚居街区可达性较差,就学人口与可达距离和学校数量负相关.按社区类型分类,工业型街区公办学校数量
Nucleic acid-based antiviral systems,including CRISPR/Cas and RNA interference,play important roles in antiviral defense.In a paper recently published in Cell Research,Wu et al.revealed a novel nucleic acid-based antiviral mechanism against RNA viruses in
True-seed potato has been the holy grail of potato breeding for decades;genetic improvement,notably resistance breeding,has lagged behind in this vegetatively propagated,polyploid staple crop.A recent study by Zhang et al.in Cell shows how genomics can gr
Sphingosine-1-phosphate (S1P) is an important bioactive lipid molecule in cell membrane metabolism and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development,physiological homeostasis,and pathogenic processes in various organs.
Coronavirus disease 2019 (COVID-19),caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflam
The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled (29 patients/grou
Telomerase,a multi-subunit ribonucleoprotein complex,is a unique reverse transcriptase that catalyzes the processive addition of a repeat sequence to extend the telomere end using a short fragment of its own RNA component as the template.Despite recent st
Circadian rhythms play an important role in balancing innate and adaptive immune responses.In a recent study in Cell Research,Zhang et al.studied the immunological response in humans to an inactivated SARS-CoV-2 vaccine administered at two different times