据报道用硝酸铈作为烧伤的局部治疗药物对革兰阴性肠杆菌效果很好。硝酸铈还可用以治疗湿疹皮肤炎、过敏性皮炎、龈炎等,并取得满意效果。我们发现硝酸铈在体外对白色念珠菌（CA）有明显的抑菌作用,在体内可降低CA感染小鼠的病死率,延长平均存活期,脏器病变好转（另文发表）。本文进而研究硝酸铈对CA感染小鼠的腹腔巨噬细胞和红细胞免疫功能的影响。1 材料和方法1.1 动物分组处理 按随机抽样法将18～22g重的昆明系小鼠（陕西省药品检验所提供）分为4组:A组（正常对照）,对小鼠不作任何处理;B组（感染对照）,尾静脉注射CA悬液0.2ml;C组（硝酸铈对照）,腹腔注射治疗剂量硝酸铈0.2ml,每天1次,连续3d;D组（感染治疗）,注射CA后即用硝酸铈治疗,每天1次,连续 3d。1.2 免疫学指标和检测方法 硝酸铈对感染小鼠外周血白细胞总数的影响用常规法;硝酸铈对感染 It has been reported that ceric nitrate as a topical treatment of burn works well against gram-negative enterobacteriaceae. Cerium nitrate can also be used to treat eczema dermatitis, atopic dermatitis, gingivitis, and achieved satisfactory results. We found that cerium nitrate has obvious bacteriostasis against Candida albicans (CA) in vitro, which can reduce the mortality of CA-infected mice in vivo and prolong the average survival period, and improve the organ disease (published separately). This article further studies cerium nitrate on CA peritoneal macrophages and erythrocyte immune function. 1 Materials and methods 1.1 Animal Grouping Treatment Randomly sampling 18 to 22g Kunming mice (provided by the Shaanxi Provincial Institute for Drug Control) were divided into 4 groups: A group (normal control), the mice without any treatment; B Group C (cerous nitrate control), intraperitoneal injection of therapeutic dose of cerium nitrate 0.2ml, once a day for 3 days; group D (infection treatment), after injection of CA Treatment with cerium nitrate, 1 day, 3 consecutive days. 1.2 Immunological indicators and detection methods of cerium nitrate on the total number of peripheral blood leucocytes infected with the conventional method; cerium nitrate infection