整合素(Integrin)分子由α和β两个亚基组成,α4整合素有α4β1和α4β7两种,它们的配体分别是VCAM-1(vascular cell adhesion molecule-1)和MAdCAM-1(mucosal adressin cell ad-hesion molecule-1)。α4整合素及其配体通过介导淋巴细胞与内皮细胞的相互作用,参与了多种生理和病理过程。抗α4的单克隆抗体(mAb),已成功地用于治疗和预防实验诱导的一些疾病。 Integrin molecules consist of two subunits, α and β. Α4 integrins have both α4β1 and α4β7. Their ligands are vascular cell adhesion molecule-1 (VCAM-1) and mucosal adressin cell ad-hesion molecule-1). α4 integrins and their ligands are involved in a variety of physiological and pathological processes by mediating the interaction of lymphocytes with endothelial cells. Anti-a4 monoclonal antibody (mAb), has been successfully used to treat and prevent some of the experimental induced diseases.