Objective To investigate the effect of invisible full-thickness mesh skin graft in the treatment of scar contracture deformity of the dorsal hand.Methods From January 2016 to February 2019, 25 patients with cicatricial contracture defor-mity of dorsal hand admitted to our hospital underwent full thickness skin graft. During the operation, the scar healed completely and the superficial fascia remained intact. The wound surface was transplanted with invisible mesh full thickness skin graft. The survival of the skin graft and the recovery of hand function and appearance in the later period were observed after the operation. Results The skin grafts of 20 patients survived with high quality, 3 cases had partial epider-mis exfoliation, and 2 cases had partial epidermis scattered in blisters. After intensive dress-ing change, all wounds healed and no complications occurred after the operation. The hand function and appearance of the patients were obviously improved. Conclusion The application of full thickness skin graft to correct scar deformity has the ad-vantages of good functional and appearance recovery and difficult postoperative contracture. Invisible full-thickness mesh skin graft is one of the ideal methods to correct scar contracture deformity of the dorsal hand.