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西苯唑啉琥珀酸盐是一个Ia类新型抗心律失常药,临床试验证明,本品抑制室性心律失常。频发性室性早搏患者多次服药后,消除半衰期7.6～22.3(平均12.3)小时,使室性早搏次数减少90％的血浆浓度为215～495ng/ml,“抗心律失常作用与血浓度成正比”。研究对象为15例室性心律失常患者,心功能Ⅰ～Ⅱ级,室性早搏次数平均每小时199次。西苯唑啉起始量32.5mg每日4次,共7日;必要时65mg或81.25mg每日
West isoxazoline succinate is a new class of anti-arrhythmic drugs Ia, clinical trials have shown that this product inhibits ventricular arrhythmias. In patients with frequent premature ventricular contractions, the elimination half-life of 7.6 to 22.3 (mean 12.3) hours, the plasma concentration of 215 ~ 495ng / ml 90% reduction in ventricular premature beats, “antiarrhythmic effect and blood concentration into Is proportional. ” The subjects were 15 patients with ventricular arrhythmia, cardiac function Ⅰ ~ Ⅱ level, the average number of ventricular premature beats 199 times per hour. The starting amount of xipoxazole 32.5mg 4 times a day for a total of 7; 65mg or 81.25mg daily if necessary