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目的:探讨长托宁在抢救急性有机磷农药中毒(AOPP)患者中的应用效果。方法:将60例AOPP患者随机分为实验组和对照组各30例,实验组采用长托宁+氯解磷定治疗,对照组采用阿托品+氯解磷定治疗。结果:实验组中毒症状消失时间、乙酰胆碱酯酶回复时间、治愈时间、治愈用药次数、不良反应与对照组比较差异有统计学意义(P<0.05,P<0.01)。结论:长托宁治疗AOPP优于阿托品,为治疗有机磷农药中毒的首选药物。
Objective: To investigate the application of penehyclidine in the treatment of patients with acute organophosphorus pesticide poisoning (AOPP). Methods: Sixty AOPP patients were randomly divided into experimental group and control group, 30 cases in each group. The experimental group was treated with penehyclidine and chlorpheniramine, while the control group was treated with atropine and chlorpheniramine. Results: There were significant differences in the disappearance time of poisoning symptoms, the recovery time of acetylcholinesterase, the healing time, the frequency of cure and the adverse reactions in the experimental group compared with the control group (P <0.05, P <0.01). CONCLUSION: Penehyclidine is better than atropine in the treatment of AOPP, which is the first choice for the treatment of organophosphorus pesticide poisoning.