1980年我科提出了胆囊结石形成的流体力学理论,并于1983年根据这一理论在体外模拟实验中首次制造出人工胆固醇结石。根据这一实验成果,我们应用相同的理论、相同的方法,在体外应用新鲜的牛胆汁成功地制造出牛胆红素钙结石-牛黄。经87次实验,成功66次,成功率达75.8％。 In 1980, our department proposed the theory of fluid mechanics for the formation of gallstones. In 1983, according to this theory, artificial cholesterol stones were first produced in in vitro simulation experiments. Based on this experimental result, we applied the same theory and the same method to successfully manufacture bovine bilirubin calcium stone, bezoar, using fresh bovine bile in vitro. After 87 experiments, 66 successes, with a success rate of 75.8%.