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柯兴氏综合征中垂体肿瘤的确实发生率很难确定。一些作者在作过尸体解剖的柯兴氏综合征患者中发现垂体腺瘤达50％,大部分腺瘤甚小,显微镜下才能识别,有X线表现或眼部征象的明显腺瘤较少见。Rynearson等观察的153例肾上腺皮质机能亢进患者中双侧肾上腺皮质增生122例,垂体腺瘤12侧(9例发生在肾上腺切除前,3例在肾上腺切除后)。Welbourn在50例柯兴氏综合征中发现14例垂体肿瘤,其中9侧在肾上腺切除前,5例在切除后。Nelson报告的44例肾上腺皮质功能亢进症中垂
The exact incidence of pituitary tumors in Cushing’s syndrome is difficult to determine. Some authors have found that pituitary adenomas reach 50% in patients with Cushing’s syndrome who have undergone autopsy. Most adenomas are very small and can be identified under a microscope. The obvious adenomas with X-ray findings or ocular signs are rare . Among 153 patients with adrenocortical hyperfunction observed by Rynearson et al., There were 122 cases of bilateral adrenal hyperplasia and 12 cases of pituitary adenoma (9 before adrenalectomy and 3 after adrenalectomy). Welbourn found 14 cases of pituitary tumors in 50 cases of Cushing’s syndrome, with 9 on the front of the adrenalectomy and 5 after the resection. Nelson reported 44 cases of adrenal hypercrosis sagging