目的观察口服环磷酰胺治疗激素耐药型小儿肾病综合征近期和远期疗效。方法对比观察临床症状、血浆蛋白与尿蛋白 ,部分病例行肾活检及随访。结果近期疗效 (1个疗程后 )完全缓解 7例 (2 5 % ) ,部分缓解 7例 (2 5 % ) ;远期疗效 (3年 )完全缓解 3例(8.8% ) ,部分缓解 2例 (5 .9% )。结论环磷酰胺在治疗激素耐药的小儿肾病中有一定的价值 Objective To observe the short-term and long-term effects of oral cyclophosphamide in the treatment of steroid-resistant nephrotic syndrome. Methods The clinical symptoms, plasma protein and urinary protein were observed and compared. In some cases, renal biopsy and follow-up were performed. Results In the short term, 7 cases (25%) were relieved completely and 7 cases (25%) partially relieved in the immediate course of treatment (1 course of treatment); 3 cases (8.8%) were relieved in long term (3 years) 5 .9%). Conclusion Cyclophosphamide has certain value in the treatment of steroid-resistant pediatric nephropathy