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盐酸二氢埃托啡(DHE)是一种新的强效麻醉性镇痛药,本文着重对DHE在啮齿类动物Do及舌下给药条件下的自然戒断,替代吗啡,催促戒断等方面的致依赖性潜力进行了研究,结果表明,DHE的致身体依赖性潜力确实较低;以DHE替代吗啡抑制阿片类戒断症状时舌下给药剂量低于po给药剂量;在一定剂量条件下DHE舌下给药可使实验动物对其产生身体依赖性。
Dihydroetorphine Hydrochloride (DHE) is a new and potent narcotic analgesic. This article focuses on the natural withdrawal of DHE from rodents in Do and sublingual administrations, replacing morphine, urging withdrawal, etc. The results showed that the DHE induced body dependence potential is indeed low; DHE instead of opiates morphine morphine withdrawal symptoms when administered sublingual dose lower than the po dose; in a certain dose Under the conditions of DHE sublingual administration can make the experimental animals on their body-dependent.