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目的:观测金思维对脑缺血大鼠空间学习记忆能力的影响。方法:金思维治疗脑缺血大鼠1个月后利用Morris水迷宫检测大鼠空间学习记忆能力并与都可喜对照。结果:1个月后,Morris水迷宫定位航行试验结果显示,从第3次游泳训练开始,金思维组、都可喜组和假手术组大鼠的逃避潜伏期均较模型组大大缩短,分别为(54.1±43.94),(55.9±43.49),(50.4±34.99),(85.4±42.8)s。第6次游泳训练后,金思维组(37.8±38.69)s、都可喜组(37.4±38.03)s、假手术组(26.9±21.63)s,大鼠的逃避潜伏期较模型组大鼠(77.5±47.59)s显著缩短,P<0.05;各组大鼠游泳路径比较结果同逃避潜伏期。空间探索试验中平台象限游泳时间和路径与总游泳时间和总路径之比结果显示,金思维组、都可喜组、假手术组显著高于模型组,P<0.05。结论:金思维能明显改善脑缺血模型大鼠空间学习记忆能力,为其改善脑缺血病人学习记忆能力的临床应用提供了药效学依据。
Objective: To observe the effect of gold thinking on spatial learning and memory in rats with cerebral ischemia. METHODS: One month after cerebral ischemia in rats treated with Golden Thinking, the Morris water maze was used to examine the spatial learning and memory ability of rats and was compared with that of both. Results: One month later, Morris water maze positioning navigation test results showed that from the third swimming training, the escape latency of Jin thought group, Duxiyin group and sham group was significantly shorter than that of the model group. 54.1 ± 43.94), (55.9 ± 43.49), (50.4 ± 34.99), (85.4 ± 42.8) s. After the sixth swimming training, Golden thinking group (37.8±38.69)s, Duxixi group (37.4±38.03) s, and sham operation group (26.9±21.63) s, the escape latency of rats was higher than that of model rats (77.5± 47.59)s were significantly shortened, P<0.05; the comparison results of swimming pathways in each group were the same as the escape latency. The ratio of swimming time and path to total swimming time and total path in the platform quadrant of the space exploration experiment showed that the gold thinking group, both the gratifying group and the sham operation group were significantly higher than the model group, P<0.05. Conclusion: Golden thinking can significantly improve the spatial learning and memory ability of rats with cerebral ischemia, and provide pharmacodynamic basis for improving the clinical application of learning and memory in patients with cerebral ischemia.