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目的研究抗老年痴呆软胶囊中五味子醇甲含量的测定方法。方法样品用甲醇回流提取进样,色谱柱:Agilent ZORBAX SB-C18柱(250mm×4.6mm,5μm),流动相:乙腈-水(45∶55),检测波长:250nm,流速:1mL·min-1。结果五味子醇甲在0.046~0.92μg之间线性关系良好,r=0.9999(n=7),平均回收率98.51%,RSD为1.84%(n=6)。结论本法简便,快速,准确,可用于本制剂及五味子药材的含量测定及质量控制。
Objective To study the determination method of schisandrol A content in anti-Alzheimer’s soft capsules. Methods Samples were extracted by refluxing with methanol. Columns: Agilent ZORBAX SB-C18 column (250mm×4.6mm, 5μm), mobile phase: acetonitrile-water (45:55), detection wavelength: 250nm, flow rate: 1mL·min- 1. Results The linear relationship between schisandrol A was between 0.046 and 0.92 μg, r=0.9999 (n=7), the average recovery was 98.51%, and the RSD was 1.84% (n=6). Conclusion This method is simple, rapid and accurate. It can be used for the determination and quality control of this preparation and Schisandra chinensis.