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目的研究静息心率的升高与2型糖尿病的患病是否存在相关性。方法于2010年采取整群抽样的方法选取上海嘉定区2519名40岁以上常住居民,进行了问卷调查、体格检查以及血液生化检测。糖尿病使用口服糖耐量试验进行诊断。静息心率用电子血压计进行测量。将人群按心率三分位,使用Logistic回归模型,分析随着心率水平的增高,糖尿病的患病风险情况。结果多重线性回归模型表明,在校正了传统危险因素后,心率与空腹血糖、餐后血糖、糖化血红蛋白和空腹胰岛素均呈显著正相关。Logistic回归表明,心率≥87次/min人群的糖尿病患病风险是心率≤76次/min人群的2.42倍(OR=2.42,95%CI 1.76~3.35)。在总人群中,心率每增加10次/min,糖尿病的患病风险则增加37%。结论在中老年人群中,静息心率的升高独立于其他的危险因素,显著增加2型糖尿病的患病风险。
Objective To investigate whether there is a correlation between resting heart rate and type 2 diabetes. Methods In 2010, 2519 residents over the age of 40 in Jiading District of Shanghai were selected by cluster sampling, and questionnaires, physical examinations and blood biochemical tests were performed. Diabetes was diagnosed using oral glucose tolerance test. Resting heart rate was measured with an electronic sphygmomanometer. The population according to heart rate tertiles, the use of Logistic regression model, analysis with the increase of heart rate, the prevalence of diabetes risk. Results The multiple linear regression model showed that after adjusting for traditional risk factors, there was a significant positive correlation between heart rate and fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin and fasting insulin. Logistic regression showed that the prevalence of diabetes in people with heart rate ≥87 beats / min was 2.42-fold (OR = 2.42, 95% CI 1.76-3.35) of the population with heart rate ≤76 beats / min. In the general population, each 10-min increase in heart rate increased the risk of diabetes by 37%. Conclusion The increase of resting heart rate in middle-aged and elderly people is independent of other risk factors and significantly increases the risk of type 2 diabetes.