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终末期肝病是急性或慢性肝病的终末阶段,常伴有肝衰竭的临床表现。目前,原位肝移植术是治疗终末期肝病最有效的方法,虽然近期疗效较好,但因其成本高及排斥反应等不足使其临床广泛应用受到了一定的限制。干细胞是具有自我更新和多向分化潜能的细胞群体,研究显示干细胞可在特定条件下分化为肝细胞,且能支持受损肝脏的再生,在治疗终末期肝病中具有广阔的前景。
End-stage liver disease is the terminal stage of acute or chronic liver disease, often accompanied by clinical manifestations of liver failure. At present, orthotopic liver transplantation is the most effective method for the treatment of end-stage liver disease. Although the recent curative effect is good, its clinical application is limited due to its high cost and rejection. Stem cells are a population of cells that have the potential for self-renewal and multidirectional differentiation. Studies have shown that stem cells can differentiate into hepatocytes under specific conditions and can support the regeneration of damaged liver, which has great prospects in the treatment of end-stage liver disease.