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目的分析扬州市2008-2014年预防接种异常反应发生特征,评估预防接种异常反应监测系统运转情况。方法通过AEFI信息管理系统收集2008-2014年报告中异常反应个案,采用描述流行病学方法分析。结果报告预防接种异常反应358例,报告发生率4.35/10万。发生异常反应疫苗构成前3位的是:麻疹风疹联合减毒活疫苗、无细胞百白破联合疫苗、麻疹减毒活疫苗,分别占报告数的15.64%、13.13%和12.01%;不同地区、不同年份和不同疫苗间异常反应发生率差异有统计学意义(χ2=65.67、38.12、691.07,均P<0.01);异常反应56.15%发生在<1岁儿童、64.53%发生在接种24 h内、78.21%发生在接种第1剂次。结论扬州市AEFI监测系统运转正常,接种疫苗的安全性在可以接受范围内。
Objective To analyze the characteristics of vaccination anomalous response in Yangzhou City from 2008 to 2014 and evaluate the operation of vaccination abnormal reaction monitoring system. Methods Awareness of abnormal reactions in 2008-2014 reports was collected through the AEFI Information Management System using descriptive epidemiological analysis. The results reported 358 cases of abnormal response to vaccination, the reported incidence of 4.35 / 100000. The first three cases of abnormal response vaccines were measles rubella combined live attenuated vaccine, cell free diphtheria combined vaccine and live attenuated measles vaccine, accounting for 15.64%, 13.13% and 12.01% of the reported cases respectively; in different regions, The incidence of abnormal reaction in different years and different vaccines was statistically significant (χ2 = 65.67,38.12,691.07, all P <0.01); 56.15% of abnormal reactions occurred in children <1 year old, 64.53% occurred within 24 hours after inoculation, 78.21% occurred in the first dose of vaccination. Conclusion The AEFI monitoring system in Yangzhou City is in normal operation and the safety of vaccination is within acceptable range.