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目的研究食道鳞癌术后复发患者的临床及病理特征与总生存的关系。方法采用回顾性队列研究的方法,搜集53例食道鳞癌根治术后复发患者的15项临床及病理因素,应用Cox回归模型行生存分析,确定预后相关风险指标,构建预后评分。结果年龄>55岁、肿瘤长径>3 cm、淋巴结转移阳性、未行术后化疗、无病生存期<6个月以及复发时白蛋白<45 g/L为术后复发患者的预后不良指标,具备0-1个指标为低危组,2-3个为中危组,4个及以上为高危组,各个组别的总生存期差别有统计学意义(P<0.0001)。结论食道鳞癌根治术后复发患者的临床及病理特征可预测预后,指导患者的治疗随访。
Objective To study the relationship between clinical and pathological features and overall survival in patients with recurrent esophageal squamous cell carcinoma. Methods A retrospective cohort study was used to collect 15 clinical and pathological factors in 53 patients with recurrent esophageal squamous cell carcinoma who underwent radical resection. Survival analysis was performed using Cox regression model to determine prognosis-related risk indicators and construct prognostic scores. Results Aged >55 years old, tumor long diameter >3 cm, positive lymph node metastasis, no postoperative chemotherapy, disease-free survival <6 months, and albumin <45 g/L at relapse were indicators of poor prognosis in patients with postoperative recurrence There were 0-1 indicators for the low-risk group, 2-3 for the middle-risk group, and 4 or more for the high-risk group. The difference in overall survival between the groups was statistically significant (P<0.0001). Conclusion The clinical and pathological features of patients with recurrent esophageal squamous cell carcinoma after recurrence can predict prognosis and guide the follow-up of patients.