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促红细胞生成素是一种造血细胞生长因子,主要用于治疗多种原因引起的贫血。近年来研究表明其具有多种非促造血方面的细胞保护作用,特别是在抑制心脏重构方面的作用日益受到广泛关注,但作用机制目前尚不十分明确,可能与抑制心肌细胞肥大和凋亡,抗炎、抗氧化,抑制成纤维细胞增殖,抑制胶原合成及影响基质金属蛋白酶活性等方面有关。其作用机制,特别是分子机制的阐明将为心血管疾病的治疗提供广阔的前景。
Erythropoietin is a hematopoietic growth factor that is mainly used to treat anemia caused by a variety of causes. In recent years, studies have shown that it has a variety of non-hematopoietic cell protection, especially in the inhibition of cardiac remodeling increasingly widespread concern, but the mechanism is not yet clear, and may be related to inhibition of myocardial hypertrophy and apoptosis , Anti-inflammatory, anti-oxidation, inhibition of fibroblast proliferation, inhibition of collagen synthesis and affect matrix metalloproteinase activity and so on. Its mechanism of action, especially the elucidation of molecular mechanisms, will provide broad prospects for the treatment of cardiovascular diseases.