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抢救有机磷农药中毒时除清除毒物外,主要措施仍是合理、正确应用阿托品及酌情根据中毒品种选用解磷定(PAM)等胆碱酯酶复活剂。有人认为“大剂量维生素B_1静注可延长PAM半衰期”而有利于抢救,因此主张应用。若用大剂量维生素B_1来延长PAM半衰期,不如直接或间歇应用PAM更为有效,何况中国药典未载有维生素B_1的静注制剂。有人用狗作试验,经静脉、皮下、口服给维生素B_1,致死量为1:6:40。亦有人给狗由静脉快速
In addition to the removal of toxic organophosphorus pesticide poisoning, the main measures are still reasonable, the correct application of atropine and, depending on the poisoning species, as appropriate, choose phosphorus (PAM) and other cholinesterase resurrection agent. Some people think that “high-dose vitamin B_1 intravenous injection of PAM half-life can be extended,” which is conducive to the rescue, so advocate the application. If large doses of vitamin B_1 to extend the half-life of PAM, as direct or intermittent use of PAM more effective, not to mention the Chinese Pharmacopoeia does not contain vitamin B_1 intravenous preparations. Some people use dogs for experiments, intravenous, subcutaneous, oral administration of vitamin B_1, the lethal dose of 1: 6:40. Some people give dogs by vein quickly