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目的:综合评价比较米非司酮加用甲氨蝶呤保守治疗异位妊娠的临床疗效。方法:选取我院2010年12月~2012年6月符合入选条件进行保守治疗的异位妊娠患者96例,所有患者随机分成观察组(n=48)和对照组(n=48),其中对照组单用米非司酮治疗,而观察组在此基础上加用甲氨蝶呤,观察2组患者治愈率,血β-HCG水平和盆腔包块恢复情况,以及血β-HCG转阴时间和住院时间。结果:观察组总有效率为93.8%,显著高于对照组总有效率77.1%(P<0.05);2组治疗后血β-HCG水平、盆腔包块均较治疗前有明显改善(P<0.05),且观察组的改善情况明显优于对照组(P<0.05);观察组血β-HCG转阴时间和住院时间明显短于对照组(P<0.05)。结论:甲氨蝶呤与米非司酮联合治疗异位妊娠,可有效提高治愈率,缩短疗程,临床值得推荐。
Objective: To evaluate the clinical efficacy of conservative treatment of ectopic pregnancy with mifepristone plus methotrexate. Methods: A total of 96 ectopic pregnancies were selected from December 2010 to June 2012 in our hospital for conservative treatment. All patients were randomly divided into observation group (n = 48) and control group (n = 48) Group mifepristone alone, while the observation group on the basis of the use of methotrexate, observed two groups of patients with cure rate, blood β-HCG levels and pelvic mass recovery, and blood β-HCG negative time And hospital stay. Results: The total effective rate in the observation group was 93.8%, significantly higher than that in the control group (77.1%, P <0.05). The blood levels of β-HCG and pelvic masses in the two groups were significantly improved after treatment (P < 0.05), and the improvement in the observation group was significantly better than that in the control group (P <0.05). The blood β-HCG negative and hospitalization time in the observation group was significantly shorter than that in the control group (P <0.05). Conclusion: Methotrexate and mifepristone combined treatment of ectopic pregnancy, can effectively improve the cure rate and shorten the course of treatment, clinical recommendations.