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目的:制备大黄素固体脂质纳米粒,并对其理化性质进行研究。方法:用乳化-溶剂挥发法制得大黄素素固体脂质纳米粒,并对其粒径、形态、表面电位、包封率、体外释药性质等进行研究。采用全体液平衡反向透析法研究体外释药性质。结果:所制固体脂质纳米粒外观形态圆整,粒度分布均匀,平均粒径为253 nm,电位为-25.4 mV,包封率为(56.31±2.06)%。药物体外释放符合Weibull线性方程。结论:固体脂质纳米粒可作为大黄素新型缓释给药系统。
Objective: To prepare emodin solid lipid nanoparticles and study its physicochemical properties. Methods: Emodin solid lipid nanoparticles were prepared by emulsification - solvent evaporation method and their particle size, morphology, surface potential, entrapment efficiency and in vitro drug release properties were studied. In vitro release properties were investigated using total fluid equilibrium reverse dialysis. Results: The morphology of the solid lipid nanoparticles was uniform and the particle size distribution was uniform. The average particle diameter was 253 nm, the potential was -25.4 mV and the entrapment efficiency was (56.31 ± 2.06)%. Drug in vitro release in line with Weibull linear equation. Conclusion: The solid lipid nanoparticles can be used as a new drug delivery system for emodin.