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目的:追踪观察鼻咽癌放疗后颈部残留灶的消退时间,并分析其影响因素。方法:选取1998年5月—2002年6月鼻咽癌放疗后有颈部残留的患者60例,追踪观察其消退时间,并应用Logistic回归分析研究年龄、性别、临床分期等7个因素对其消退时间的影响。结果:80%的患者颈部残留灶可以在放疗结束后3个月内消退。单因素Logistic回归分析显示性别、N分期、化疗3个因素与颈部残留灶的消退有关;多因素Logistic回归分析表明仅有N分期、化疗2个因素影响颈部残留灶的消退。化疗与颈部残留灶的消退时间呈正相关,而N分期则与消退时间呈负相关。结论:鼻咽癌放疗后颈部残留灶大部分可在放疗结束后3个月内消退,影响消退的因素主要有N分期及化疗。
OBJECTIVE: To observe the regression time of residual neck in patients with nasopharyngeal carcinoma after radiotherapy and analyze the influencing factors. Methods: From May 1998 to June 2002, 60 patients with residual neck after radiotherapy of nasopharyngeal carcinoma were selected. The regression time was observed. Logistic regression analysis was used to analyze the effects of age, sex, clinical stage and so on The effect of subsided time. Results: 80% of the patients with residual neck lesions can be resolved within 3 months after the end of radiotherapy. Univariate logistic regression analysis showed that gender, N stage and chemotherapy were related to the regression of residual neck. Multivariate logistic regression analysis showed that only N stage and chemotherapy were the two factors that affected neck subsidence. Chemotherapy and cervical residual foci regression time was positively correlated, while the N stage and regression time was negatively correlated. Conclusion: Most of the residual cervical lesions after radiotherapy of nasopharyngeal carcinoma can be dissipated within 3 months after the end of radiotherapy. The main factors affecting the regression are N stage and chemotherapy.