本文报告3例以慢性难治性疼痛为主要临床表现的多发性硬化(MS)。例1:61岁、男,诉剧烈左臀和腿痛4年。痛位于肛门左侧,呈隐袭性起病,按痔治疗无效,缓慢进展并扩展至坐骨切迹和股后区,呈持续中一重度刺或牵拉痛,步行时加重。伴体重下降, This article reports three cases of chronic refractory pain as the main clinical manifestations of multiple sclerosis (MS). Example 1:61 years old, male, v. Severe left hip and leg pain for 4 years. Pain in the left side of the anus was cryptogenic onset, according to hemorrhoid treatment ineffective, slow progress and extended to the sciatic notch and posterior area, was sustained in a severe thorn or pulling pain, walking heavier. With weight loss,