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目的 研究糖皮质激素诱导大鼠骨质疏松模型及依扑拉芬对糖皮质激素引起大鼠骨质疏松的防治作用。方法 ｉｍ 氢化泼尼松４－５ ｍｇ·ｋｇ－１ ，每周２ 次，共８ ｗｋ 可引起大鼠体重明显降低，血清有机磷含量和碱性磷酸酶活性升高，尿钙浓度和２４ ｈ 尿钙排泄量增加以及骨灰重降低，引起大鼠骨密度降低导致骨质疏松。结果 氢化泼尼松（４－５ ｍｇ·ｋｇ－ １ ，ｉｍ ，每周２ 次，共８ ｗｋ） 可诱导大鼠骨质疏松模型，而依扑拉芬（１００、２００ 与４００ ｍｇ·ｋｇ－１）对糖皮质激素引起的大鼠体重降低，血清ｐｉ 含量及碱性磷酸酶活性升高，尿钙排泄量增加和骨灰含量以及骨密度降低均有拮抗作用。结论 依扑拉芬对糖皮质激素引起的大鼠骨质疏松有良好的防治作用
Objective To study the model of glucocorticoid-induced osteoporosis in rats and the effect of emblaoptin on glucocorticoid-induced osteoporosis in rats. Methods im-prednisone 4-5 mg · kg-1, twice a week for 8 weeks can significantly reduce body weight, serum organic phosphorus and alkaline phosphatase activity, urinary calcium concentration and 24 h Increased urinary calcium excretion and reduced bone weight lead to decreased bone mineral density in rats leading to osteoporosis. Results Prednisolone (4-5 mg · kg-1, im, twice a week for 8 weeks) induced osteoporosis in rats, 1) Glucocorticoid-induced rat weight loss, elevated serum pi content and alkaline phosphatase activity, increased urinary calcium excretion and ascites content and decreased bone mineral density were antagonistic. Conclusion Toxoprofen has a good preventive and therapeutic effect on glucocorticoid-induced osteoporosis in rats