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检测６２例哮喘患儿血浆中一氧化氮（ＮＯ）和血清白细胞介素６（ＩＬ６）含量。以探讨其在气道炎症形成中的作用。结果表明：对照组（ｎ＝３３）ＮＯ含量为２８±１３．５ｕｍｏｌ／Ｌ，ＩＬ６阳性率仅为２／３３。哮喘发作期（ｎ＝３１）明显高于对照组。分别为４７．９±２０．０４和１７／３１（Ｐ＜０．０１）。而缓解期（ｎ＝３１）ＩＬ６阳性率为８／３１，明显高于对照组（Ｐ＜０．０１）。而缓解期（ｎ＝３１）ＩＬ６阳性率为８／３１，明显高于对照组（Ｐ＜０．０１），但较发作期为低（Ｐ＜０．０５）。提示ＮＯ和ＩＬ６可能参与发作期气道炎症的形成，ＩＬ６在缓解期慢性炎症的持续中具有重要作用。
The plasma levels of nitric oxide (NO) and serum interleukin 6 (IL6) were measured in 62 asthmatic children. To explore its role in the formation of airway inflammation. The results showed that the content of NO in control group (n = 33) was 28 ± 13.5umol / L and the positive rate of IL6 was only 2/33. Asthma exacerbation (n = 31) was significantly higher than the control group. Respectively 47.9 ± 20.04 and 17/31 (P <0.01). The remission (n = 31) IL6 positive rate was 8/31, significantly higher than the control group (P <0.01). In remission (n = 31), the positive rate of IL6 was 8/31, which was significantly higher than that of control group (P <0.01), but lower than that of seizure (P <0.05). It is suggested that NO and IL6 might be involved in the pathogenesis of airway inflammation during the seizure phase. IL6 plays an important role in the persistence of chronic inflammation during remission.