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给恒河猴皮下埋藏含睾酮(100μg/kg/日)加雌二醇(0.5μg/kg/日)聚二甲硅氧烷(PDS;Sila-stic)13个月。该类固醇配方通过垂体前叶抑制LH 分泌,但不抑制 FSH 分泌;抑制睾丸的睾酮和雌二醇生成,大幅度减低射精的精子计数、活力和活率。当正常恒河猴的睾丸机能受到上述影响时,所用的睾酮和雌二醇的剂量与每天内源性产生这两种类固醇的量近似。材料和方法:选择20只成熟恒河猴分成两组。对照组10只,皮下埋藏装满胆固醇的 PDS。处理组10
Rhesus macaques were subcutaneously implanted with testosterone (100 μg / kg / day) plus estradiol (0.5 μg / kg / day) polydimethylsiloxane (PDS; Sila-stic) for 13 months. The steroid formulation inhibits LH secretion by the anterior pituitary, but does not inhibit FSH secretion; inhibits testosterone and estradiol production in the testes, greatly reducing sperm count, viability and viability of ejaculation. When testicular function in normal rhesus monkeys is affected as described above, the dose of testosterone and estradiol used is similar to the amount of both steroids produced endogenously per day. Materials and Methods: Twenty mature Rhesus macaques were divided into two groups. Control group of 10, buried under the skin filled with cholesterol PDS. Processing group 10