【摘 要】
：
An efficient biocatalytic process has been developed to obtain optically pure(1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol which can be used as the key
【机 构】
：
State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology,
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
An efficient biocatalytic process has been developed to obtain optically pure(1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol which can be used as the key intermediate of ticagrelor. In this research, several N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol derivatives have been investigated in which Candida antarctica lipase B(CALB) was used to catalyze the asymmetric hydrolysis reaction. As expected, some of these substrates successfully gave(1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol in >98% enantiomeric excess(ee) with conversion yields up to 45%.
An efficient biocatalytic process has been developed to obtain optically pure (1S, 4R) -N- (benzylcarbamoyl) -4-aminocyclopent-2-en-1-ol which can be used as the key intermediate of ticagrelor. In this research, several N- (benzylcarbamoyl) -4-aminocyclopent-2-en-1-ol derivatives have been investigated in which Candida antarctica lipase B (CALB) was used to catalyze the asymmetric hydrolysis reaction. As expected, some of these substrates were successfully given (1S , 4R) -N- (benzylcarbamoyl) -4-aminocyclopent-2-en-1 in> 98% enantiomeric excess (ee) with conversion yields up to 45%.
其他文献
An efficient and high-yielding synthesis of N~2-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines and 2-methylthio-pyrimidine-5-carbonitri
Two novel interpenetrating diamond frameworks,namely [Cd(mal)(bix)]n(1) and {[Zn(sub)(bib)]n·H2O}n(2)(H2mal=maleic acid,H2 sub=suberic acid,bix=1,4-bis(imidazo
【摘 要】汽车零部件产业是荆州市的支柱产业之一。本文从荆州现有零部件企业物流存在的问题出发，提出以供应链成本来考量，最终落脚点是目标成本法。 【关键词】供应链成本；荆州；汽车零部件；物流 2009年，荆州市汽车零部件产业发展势头良好，全年产值77.5亿元，同比增长33.16％，占荆州工业总产值的10.54％。目前，荆州市拥有汽车零部件企业160余家，其中规模以上汽车零部件企业81
A novel copper-catalyzed dual oxidative benzylic C–H aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. Thi
A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the react
The effect of potassium(K) promoter on the catalytic performance of activated carbon(AC) supported Wacker-type catalysts(Pd Cl2–Cu Cl2/AC) for the synthesis of
<正> 唐华清宫遗址位于今陕西省临潼县城南,骊山北麓,是唐朝皇帝为洗沐温泉而专设的行宫。初唐时期,华清宫又名汤泉宫或温泉宫,据宋人宋敏求《长安志》“贞观十八年(644年),诏左屯卫大将军姜行本,将作少匠阎立德营建宫殿,御赐名‘汤泉宫’,太宗因幸制碑。(唐高宗)咸亨二年(671年)改名温泉宫。(唐玄宗)天宝六年(747年)又改为华清宫”。据史书记载,在骊山温泉修建汤池殿宇始自秦汉时期。当时,在贵族间盛行由中亚地区传进的“温汤疗疾”的习俗,相信温泉
李白的《蜀道难》一诗,起首便是那骇人的惊叹:“噫,吁唏！危乎高哉。蜀道之难难于上青天！” 然而,令人慨叹的尚不止是蜀道的难行,能在这黄鹤难飞,猿揉难攀的崇山绝(山献)之上开
<正>一 1995年6月26日至7月8日,在芬兰北卡莱利亚省的麦克里雅日维(约恩苏大学的研究站),举办了第三届国际民俗学会暑期研修班(Folklore Fellows’ Summer School)。国际民俗学会是民俗学领域最具权威的国际性学术团体,迄今已有近百年历史,会员为来自世界各地的知名民俗学家,由于它遴选会员上一向十分严格,现今正式会员限制在百人以内。该团体主办过多次国际学术活动,影响十分广泛。暑期研修班即是其定期举办的活动之一,自1991年开始,每两年进行一次。由于得到了多方面的
日前,比亚迪董事长王传福在路演活动中传递的一条信息——比亚迪汽车动力电池研发团队已突破千人——实际上这才是比亚迪的底气。比亚迪宣布,E6纯电动汽车今年下半年就将正式