目的:探讨急诊ICU床旁应用血液灌流治疗急性重症有机磷中毒临床疗效。方法:2012年急性重症有机磷中毒患者给予常规治疗措施,2013年患者在常规治疗基础上加用血液灌流联合治疗,记录两组患者清醒时间、胆碱酯酶活力恢复时间、住院时间。结果:2013组患者在清醒时间、住院时间及胆碱酯酶活力恢复时间均显著少于2012组,提示2013组患者救治效果更为显著,两组对比结果具有统计学意义(P<0.05)。结论:应用常规治疗与血液灌流联合救治急性重症有机磷中毒患者可获得满意疗效,保障患者预后及生活质量,有利于其尽快恢复健康,值得今后工作中推广应用。 Objective: To investigate the clinical effect of applying hemoperfusion on the bedside of emergency ICU in the treatment of acute severe organophosphate poisoning. Methods: Patients with acute severe organophosphorus poisoning in 2012 were given routine treatment. In 2013, patients were treated with hemoperfusion combined with routine therapy. The recovery time and hospital stay of cholinesterase were recorded. Results: The recovery time of patients in 2013 group was significantly shorter than that in 2012 group in awake time, hospital stay and recovery of cholinesterase activity, suggesting that the treatment effect in 2013 group was more significant. The comparison between the two groups was statistically significant (P <0.05). Conclusion: The combination of conventional therapy and hemoperfusion can effectively improve the prognosis and quality of life of patients with acute severe organophosphate poisoning, which is beneficial to their recovery as soon as possible and is worth popularizing and applying in future work.