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目的 :探讨调脂对急性冠状动脉 (冠脉 )综合征 (ACS)患者冠脉病变炎症的影响。方法 :采用随机、对照方法将 12 5例ACS患者 (在常规治疗下 )分为他汀治疗组 (6 3例 )和非他汀治疗组 (6 2例 ) ,另选健康对照者6 0例作为对照组。测定在治疗前、治疗后 8周血浆高敏C 反应蛋白 (HS CRP)、P 选择素、氧化修饰低密度脂蛋白 (ox LDL)、血清一氧化氮 (NO)水平的变化。结果 :①ACS患者的血浆HS CRP、P 选择素、ox LDL水平明显增高 ,血清NO水平明显降低 ,血浆HS CRP、P 选择素水平与ox LDL、血清NO水平有明显直线相关性。②他汀治疗组在治疗 8周后其血浆HS CRP、P 选择素与ox LDL水平明显下降 ,血清NO水平明显上升 ,非他汀治疗组各项指标无明显变化。结论 :他汀调脂可阻滞ACS患者冠脉病变的炎症反应。
Objective: To investigate the effect of lipid-lowering on coronary artery inflammation in patients with acute coronary syndrome (ACS). Methods: A total of 125 ACS patients (63 undergoing routine treatment) were divided into statin group (62 cases) and non-statin group (62 cases) by randomized and controlled methods, and 60 healthy controls were selected as control group. The changes of plasma CRP, P-selectin, ox LDL and serum nitric oxide (NO) levels were measured before treatment and 8 weeks after treatment. Results: ① The plasma levels of HS CRP, P-selectin and ox LDL in patients with ACS were significantly increased, while the levels of serum NO were significantly decreased. The levels of plasma HS CRP and P-selectin were linearly correlated with ox LDL and serum NO levels. ② In the statin treatment group, the plasma levels of HS CRP, P-selectin and ox LDL were significantly decreased after 8 weeks of treatment, and the level of serum NO was significantly increased. There was no significant change in the non-statin treatment group. Conclusion: Statin lipid-lowering can block the inflammatory response of coronary artery in patients with ACS.