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有些药物突然停用,会导致疾病复发、加重、恶化,甚至酿成更大的危险。 1、肾上腺皮质激素类:如考的松、强的松和地塞米松等长期使用,可反馈性抑制下丘脑——垂体——肾上腺系统,使促肾上腺皮质激素分泌减少,引起肾上腺皮质萎缩或功能不全,若骤然停药可使原疾病复发和恶化,出现“反跳”现象,甚至可发生“肾上腺皮质危象”。表现为厌食、恶心、呕吐、乏力、疲倦、昏迷等。为减轻停药反应,可模拟激素自然分泌的昼夜规律投药,即将皮质激素一日量于早晨7点服;撤药时必须逐渐减量,缓慢停药,每月只能递减1毫克强的松龙或相当量的其他类固醇;也可同时注射促肾上腺皮质激素,促使肾上腺皮质功能恢复。在停药后数月中,为避免出现肾上腺皮质危象,如遇大手术、创伤、大失血、
Sudden withdrawal of some drugs can lead to recurrence, aggravation, deterioration and even greater risk. 1, adrenal cortex hormones: such as the test of cortisone, prednisone and dexamethasone and other long-term use, feedback inhibition of the hypothalamus - pituitary - adrenal system, so that adrenocorticotropic hormone secretion decreased, causing adrenal cortex atrophy or Incomplete, if sudden withdrawal can make the original disease recurrence and deterioration, there “rebound” phenomenon, and even “adrenal crisis.” The performance of anorexia, nausea, vomiting, fatigue, fatigue, coma and so on. In order to reduce the withdrawal response, can simulate natural secretion of hormones day and night regular administration, about the amount of corticosteroids in the morning at 7 o’clock in the morning; withdrawal must gradually tapering, slow withdrawal, only 1 mg per month, prednisone Dragon or a considerable amount of other steroids; also injection of adrenocorticotropic hormone, to promote adrenal function recovery. In the few months after the withdrawal, in order to avoid adrenal crisis, in case of major surgery, trauma, blood loss,