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目的观察含左氧氟沙星三联疗法根除幽门螺旋杆菌(H·pylori)的疗效。方法将98例H·pylori阳性的消化性溃疡患者,随机分成治疗组与对照组,每组49例。治疗组采用左氧氟沙星、雷贝拉唑、阿莫西林治疗。对照组采用甲硝唑、雷贝拉唑、阿莫西林治疗。疗程结束后4周,复查胃镜并检测H·pylori,记录患者H·pylori根除以及溃疡愈合率情况。结果 98例均完成治疗方案,治疗组与对照组H·pylori根除率分别为89.7%、81.6%,差异有统计学意义(P<0.05);溃疡愈合率分别为91.8%、87.7%,差异无统计学意义(P>0.05)。结论左氧氟沙星、雷贝拉唑、阿莫西林三联疗法在消化性溃疡患者中有很高的H·pylori根除率,是安全有效的H·pylori根除方案。
Objective To observe the efficacy of levofloxacin triple therapy in the eradication of H. pylori infection. Methods 98 cases of H. pylori positive peptic ulcer patients were randomly divided into treatment group and control group, 49 cases in each group. Treatment group using levofloxacin, rabeprazole, amoxicillin treatment. The control group with metronidazole, rabeprazole, amoxicillin treatment. Four weeks after the end of treatment, gastroscopy was performed and H · pylori was detected. H · pylori eradication and healing rate of ulcer were recorded. Results The treatment regimen was completed in 98 cases. The eradication rates of H · pylori in treatment group and control group were 89.7% and 81.6%, respectively (P <0.05). The healing rates of ulcer were 91.8% and 87.7% respectively, with no difference Statistical significance (P> 0.05). Conclusions Levofloxacin, rabeprazole and amoxicillin triple therapy have a high H · pylori eradication rate in patients with peptic ulcer, which is a safe and effective H · pylori eradication program.