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本文用放免法测定了妊娠35～67d妇女口服米非司酮100mg前和48h后血浆中E2、P、PRL、βhCG水平和妊娠40～56d口服米非司酮48h后蜕膜和绒毛组织中的PG（2α）、PGE2、TXB2和6－keto－PGF（1α）水平的变化。结果显示米非司酮使血浆P水平降低（P＜0．01）；PRL水平增加（P＜0．01）；E。在用药后48h继续呈上升趋势，但与用药前无显著统计学差异；E2／P和PRL／P比值增力。（P＜0．05，P＜0．01）。6－keto－PGF（1α）在用药后有腹痛和／或子宫出血受试者蜕膜组织中的水平明显高于无症状受试者和对照组；绒毛组织中PGF（2α）、TXB2和6－keto－PGF（1α）水平在用药后有腹痛和／或子宫出血者和无症状受试者都明显高于对照组（P＜0．05，P＜0．005），PGF（2α）／PGE2比值也明显增加（P＜0．05）。结果显示了来非司酮对早孕妇女的综合影响，包括改变内分泌激素之间和PGS之间比率的平衡，改变内分泌激素和PGs的浓度，促使子宫收缩及宫颈软化等。
In the present study, the levels of E2, P, PRL, βhCG in plasma and the levels of E2, P, PRL and βhCG in plasma of 35-67 d pregnant women before oral administration of mifepristone and 48 h after oral administration of mifepristone were measured by radioimmunoassay Changes in PG (2α), PGE2, TXB2 and 6-keto-PGF (1α) levels. The results showed that mifepristone decreased the level of plasma P (P <0.01) and the level of PRL increased (P <0.01). 48h after treatment continued upward trend, but no significant difference with the medication before; E2 / P and PRL / P ratio increased power. (P <0.05, P <0.01). The levels of 6-keto-PGF (1α) in decidual tissue of subjects with abdominal pain and / or uterine bleeding after treatment were significantly higher than those of asymptomatic subjects and controls; the levels of PGF (2α), TXB2 and 6 The levels of -keto-PGF (1α) in patients with abdominal pain and / or uterine bleeding and asymptomatic subjects were significantly higher than those in the control group (P <0.05, P <0.005) PGE2 ratio also increased significantly (P <0.05). The results show the combined effects of propofol on early pregnant women, including changing the balance between endocrine hormones and PGS, changing the concentration of endocrine hormones and PGs, and promoting uterine contractions and cervical softening.