目的了解珠海市斗门区人群甲型H1N1流感病毒感染状况及抗体水平,探讨影响普通人群血清甲型H1N1流感病毒抗体阳性的因素。方法采用多阶段随机抽样方法,从斗门区2个镇选取480人进行问卷调查,并采集血液标本进行甲型H1N1流感病毒血凝抑制(HI)检测。结果甲型H1N1流感抗体阳性人数为110人,阳性率为22.92%(110/480)。单因素和多因素二项Logistic分析均显示职业、接种甲型H1N1流感疫苗、调查前曾患过感冒与血清甲型H1N1流感病毒抗体阳性有关。结论珠海市斗门区人群甲型H1N1流感病毒抗体水平不高。接种甲型H1N1流感疫苗是预防甲型H1N1流感的重要手段。 Objective To understand the prevalence and antibody level of Influenza A (H1N1) virus in Doumen District of Zhuhai City and to explore the factors influencing the antibody positive to the Influenza A (H1N1) virus in the general population. Methods A multi-stage random sampling method was used to select 480 people from 2 towns in Doumen District for questionnaire survey. Blood samples were collected for the detection of hemagglutination inhibition (HI) of Influenza A (H1N1) virus. Results The positive number of Influenza A (H1N1) antibody was 110 and the positive rate was 22.92% (110/480). Univariate and multivariate logistic analysis showed that the occupational vaccination of influenza A (H1N1) vaccine was related to the positive serum of influenza A (H1N1) virus before the investigation. Conclusion The level of antibodies against influenza A (H1N1) in Doumen District of Zhuhai City is not high. Vaccination with influenza A (H1N1) is an important means of preventing influenza A (H1N1).