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目的探讨髓过氧化物酶(MPO)在吸烟与胰腺癌发病关系中的作用。方法采用病例-对照研究设计。病例组为71例经病理证实的新发胰腺导管腺癌患者,对照组为71例按照性别、年龄进行匹配的健康人群。采用自制调查表进行面对面问卷调查。调查内容包括年龄、性别、体质指数(BMI)、吸烟、饮酒、糖尿病史等。采集研究对象治疗前的静脉血,采用酶联免疫分析方法检测其血浆MPO浓度。以对照组MPO浓度的中位数作为界值,将研究对象MPO浓度分为高和低两组。采用多元非条件Logistic回归分析方法分别探讨吸烟与胰腺癌、吸烟与高MPO浓度胰腺癌、吸烟与低MPO浓度胰腺癌的关系。结果在控制年龄、性别、饮酒、BMI的情况下,吸烟者发生胰腺癌的风险升高(OR=2.74,95%CI:1.12-6.74;P=0.028);将病例组按照MPO浓度(196 IU/L)进行分层后,发现吸烟与高MPO浓度胰腺癌有关(OR=3.81,95%CI:1.17-12.44;P=0.026),但与低MPO浓度胰腺癌无相关(OR=2.51,95%CI:0.82-7.72;P=0.108)。结论吸烟可能导致胰腺癌的发病风险升高。血浆MPO浓度升高可能在吸烟与胰腺癌关系中起作用。
Objective To investigate the role of myeloperoxidase (MPO) in the relationship between smoking and pancreatic cancer. Methods A case-control study design was used. The case group was 71 cases of newly diagnosed pancreatic ductal adenocarcinoma confirmed by pathology, and the control group consisted of 71 healthy people matched by sex and age. Self-made questionnaire for face-to-face questionnaires. The survey included age, gender, body mass index (BMI), smoking, drinking, history of diabetes and more. Blood samples were collected before treatment, and plasma concentrations of MPO were detected by enzyme-linked immunosorbent assay. The median MPO concentration in the control group as a cutoff, the study object MPO concentrations were divided into high and low groups. Multivariate non-conditional Logistic regression analysis was used to investigate the relationship between smoking and pancreatic cancer, smoking and MPO-rich pancreatic cancer, smoking and low-MPO pancreatic cancer. Results The risk of pancreatic cancer in smokers increased with age, sex, alcohol intake and BMI (OR = 2.74, 95% CI: 1.12-6.74; P = 0.028) (OR = 3.81, 95% CI: 1.17-12.44; P = 0.026), but was not associated with low MPO concentration in pancreatic cancer (OR = 2.51, 95 % CI: 0.82-7.72; P = 0.108). Conclusion Smoking may increase the risk of pancreatic cancer. Increased plasma MPO levels may play a role in the relationship between smoking and pancreatic cancer.