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目的 :探讨 C- erb B- 2癌基因蛋白在乳腺肿瘤中的表达情况及临床意义。方法 :应用免疫组化 SP法 ,对 12 6例乳腺良恶性肿瘤进行 C- erb B- 2癌基因蛋白检测 ,对其中 97例乳腺癌进行雌激素受体 (ER)和孕激素受体 (PR)检测。结果 :C- erb B- 2蛋白阳性表达的细胞主要为癌细胞。C- erb B- 2蛋白在导管内癌、Paget’s病及浸润性导管癌中呈高表达 ,在浸润性小叶癌中均呈阴性表达。C- erb B- 2蛋白呈阴性表达又无淋巴结转移者 ,10 a生存率较高。结论 :C- erb B- 2蛋白表达既可用于鉴别乳腺良恶性病变和乳腺癌的早期诊断 ,也可作为判断乳腺癌预后的一项独立指标
Objective: To investigate the expression of C-erb B-2 oncogene protein in breast cancer and its clinical significance. Methods: C-erb B-2 oncogene protein was detected in 12 6 cases of breast benign and malignant tumors by immunohistochemical SP method. The expressions of ER and PR ) Test. Results: C-erb B-2 protein positive cells were mainly cancer cells. C-erb B-2 protein is overexpressed in ductal carcinoma, Paget’s disease and invasive ductal carcinoma, and negative in invasive lobular carcinoma. C-erb B-2 protein negative expression without lymph node metastasis, 10 a higher survival rate. Conclusion: The expression of C-erb B-2 protein can be used to distinguish benign and malignant breast lesions from early diagnosis of breast cancer, and can also be used as an independent indicator to judge the prognosis of breast cancer