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为了评价肾综合征出血热乳鼠脑和沙鼠肾疫苗的安全性、血清学效果、流行病学保护效果、有无免疫增强，以及研究疫苗的免疫策略，１９９４年在陕西省部分高发疫区建立了两类疫苗的接种组和对照组实验人群，并对各评价指标作了４年的观察研究。结果两种疫苗反应轻微。基础免疫后２周、加强前、加强后２周、１年、２年、３年，乳鼠脑和沙鼠肾疫苗中和抗体阳转率分别为７８５７％、７８４％、５２９４％、４５％、１０００％、２３５３％和７３０８％、２７４５％、７６４７％、４０００％、３０００％、２９４１％。乳鼠脑和沙鼠肾疫苗各年的保护率分别为９５１３％、１００００％、８７６０％、８０１３％和９８２３％、９４４５％、１００００％、７４０６％。未发现有免疫增强现象。表明两类疫苗安全性好，无免疫（感染）增强现象，中和抗体阳性率呈逐年下降趋势。保护率前３年均在８７％以上，第４年有所下降。在陕西省疫苗接种时间以每年４～５月或９～１０月为宜，接种年龄应为１０岁以上。
In order to evaluate the safety, serological efficacy, epidemiological protective effect, immune enhancement and vaccine immunization strategy in neonatal rat brain and gerbil with renal syndrome hemorrhagic fever with hemorrhagic fever, the immunization strategy was established in some high incidence areas of Shaanxi Province in 1994 Inoculation group and control group of two kinds of vaccine experimental population, and each evaluation index made a 4-year observation. As a result, the two vaccines reacted slightly. The positive rate of neutralizing antibody in neonatal rat brain and gerbil was 7857%, 784%, 525 respectively after 2 weeks, 2 weeks, 1 year, 2 years and 3 years after boosting. 94%, 45%, 1000%, 2353% and 7308%, 2745%, 7647%, 4000%, 3000%, 2941% respectively. The protection rates of neonate and neonatal Nephrotic vaccine were 9513%, 10000%, 8760%, 8013% and 9823%, 9445%, 10000%, 74 06%. No immune enhancement was found. These two vaccines showed good safety and no immune (infection) enhancement. The positive rate of neutralizing antibody showed a declining trend year by year. The protection rate was above 87% in the first three years and declined in the fourth year. Vaccination time in Shaanxi Province every year from April to May or September to October is appropriate, vaccination age should be 10 years of age or older.