肺癌表皮生长因子受体表达增强,能自分泌表皮生长因子和(或)转化生长因子-α,形成自分泌环,在肺癌的发生、转移中可能起重要作用。抗表皮生长因子受体单抗能竞争性地抑制受体与配体的结合,抑制受体酪氨酸蛋白激酶活性,体内外实验表明对肺癌有抑制作用。抗表皮生长因子受体单抗可能成为一种安全,有效的肺癌治疗新方法。 Increased expression of epidermal growth factor receptors in lung cancer, autocrine epidermal growth factor and (or) transforming growth factor-α, the formation of autocrine loop, may play an important role in the occurrence and metastasis of lung cancer. Anti-epidermal growth factor receptor monoclonal antibodies can competitively inhibit the binding of receptors to ligands and inhibit the activity of receptor tyrosine protein kinases. In vitro and in vivo experiments have shown that they have inhibitory effects on lung cancer. Anti-EGFR receptor monoclonal antibodies may become a safe and effective new treatment for lung cancer.